Form: 144

Report of proposed sale of securities

144: Filer Information

144: Issuer Information

144: Securities Information

Title of the Class of Securities To Be SoldName and Address of the BrokerNumber of Shares or Other Units To Be SoldAggregate Market ValueNumber of Shares or Other Units OutstandingApproximate Date of SaleName the Securities Exchange
Common Stock
J.P. Morgan Securities LLC
270 Park Avenue, 10th Floor
New York   NY   10017
189326576982918865911/11/2025
NASDAQ


Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the ClassDate you AcquiredNature of Acquisition TransactionName of Person from Whom AcquiredIs this a Gift?Date Donor AcquiredAmount of Securities AcquiredDate of PaymentNature of Payment *
Common Stock12/29/2023ISOIssuerCheckbox not checked800012/29/2023Cash
Common Stock04/05/2019Founder SharesIssuerCheckbox not checked1093204/05/2019Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.



Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of SellerTitle of Securities SoldDate of SaleAmount of Securities SoldGross Proceeds
Kristen M. Oelschlager
C/o Castle Biosciences, Inc.
505 S. Friendswood Drive, Suite 401
Friendswood   TX   77546
Common Stock08/27/202512677279140
Kristen M. Oelschlager
C/o Castle Biosciences, Inc.
505 S. Friendswood Drive, Suite 401
Friendswood   TX   77546
Common Stock10/31/202512678317503
The Fritz Shorter Trust
C/o Castle Biosciences, Inc.
505 S. Friendswood Drive, Suite 401
Friendswood   TX   77546
Common Stock08/27/202518007390595

144: Remarks and Signature